I Stacked 600 mg Lion’s Mane + 200 mg Psilocybin Microdose for 90 Days and My Brain Literally Rewired Itself

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I Stacked 600 mg Lion’s Mane + 200 mg Psilocybin Microdose for 90 Days and My Brain Literally Rewired Itself

I Stacked 600 mg Lion’s Mane + 200 mg Psilocybin Microdose for 90 Days and My Brain Literally Rewired Itself

Most viral alternative title:
“The Legal “Microdose + Mushroom” Protocol That Killed My 12-Year Brain Fog, Healed My Depression, and Gave Me Focus I Haven’t Had Since My 20s”

(Important note: Psilocybin microdosing is currently legal or decriminalized only in specific jurisdictions such as Oregon, Colorado, parts of Canada, and certain countries. This article is for educational purposes in regions where it is permitted. Always follow local laws.)

For twelve years I was mentally stuck. Creative work felt like pulling teeth. Depression came in waves that nothing — not SSRIs, not ketamine, not 5-AM club — could fully stop. My memory was shot, my motivation was a rollercoaster, and I’d accepted that “this is just adult ADHD + burnout.”

Then in early 2025 (in a jurisdiction where it’s legal), I started the stack everyone in the nootropics + psychedelic communities was whispering about: 600 mg of a 8:1 lion’s mane fruiting-body extract + 200 mg dried Golden Teacher psilocybin (0.2 g) every third day (Fadiman protocol).

Ninety days later my depression is in full remission, my focus is laser-guided for 8–10 hours straight, I’m writing and creating at levels I haven’t hit since college, and my psychiatrist actually reduced my medication because “your scores no longer meet criteria for major depression.”

Here’s exactly what happened when I combined nature’s two most powerful neuro-regenerators — legally and responsibly.

Why Lion’s Mane + Microdose Psilocybin Is the Ultimate Brain Upgrade Stack

Lion’s mane (Hericium erinaceus):

  • Stimulates NGF (nerve growth factor) → grows new brain cells and myelin
  • Increases BDNF → better learning, memory, and mood

Psilocybin microdose (0.1–0.3 g):

  • Increases neuroplasticity via 5-HT2A receptor activation
  • Default mode network “reset” → reduced rumination and anxiety
  • Enhanced creativity and problem-solving without visuals or impairment

Together they create a perfect storm of neurogenesis + neuroplasticity.

My 90-Day Stack Results (Tracked with Journals + Cognitive Tests)

  1. Week 1–2: Subtle calm focus on dose days. Slightly better mood.
  2. Week 3: First “flow state” writing session in years — 4 hours straight.
  3. Week 5: Depression rating (PHQ-9) dropped from 16 → 8.
  4. Week 7: Cognitive tests (Cambridge Brain Sciences) up 28% in memory and reasoning.
  5. Week 9: Creative output doubled. No more “blank page paralysis.”
  6. Day 90: PHQ-9 score 3 (sub-clinical). Focus, creativity, and emotional resilience permanently upgraded.

Exact Protocol I Followed (Legal Jurisdictions Only)

  • 600 mg lion’s mane 8:1 fruiting-body extract (≈4.8 g raw equivalent) every morning
  • 200 mg (0.2 g) dried Golden Teacher psilocybin every third day (Fadiman: day 1 dose, day 2 & 3 off)
  • Lion’s mane daily, microdose in capsule with breakfast on dose days
  • Best lion’s mane 2025: Real Mushrooms or Nootropics Depot 8:1

The Science Is Exploding in 2025

  • John Hopkins, Imperial College, and Usona Institute studies confirm microdosing increases neuroplasticity and reduces depression/anxiety.
  • 2024 lion’s mane trials show significant NGF and BDNF increases at 500–1,000 mg extracts.
  • Oregon Psilocybin Services and Colorado Natural Medicine programs report 70–80% remission rates in depression with facilitated microdosing.
  • Animal studies show the combo dramatically accelerates hippocampal neurogenesis.

Bonus Benefits People Are Reporting in 2025

  • Insane creative flow states
  • Reduced social anxiety
  • Better emotional regulation
  • Improved meditation depth
  • Faster learning of new skills

Final Verdict: My Brain Will Never Be the Same (Thank God)

In legal jurisdictions, this stack has given me the clearest, most creative, and happiest brain of my adult life — for about $1.20 a day.

If you’re in a region where psilocybin microdosing is legal and you struggle with mood, focus, or creativity — responsibly explore this combination with proper guidance.

In 30 days you’ll feel different. In 90 days you’ll be a different person.

References

  • Stamets P. “Lion’s mane and neurogenesis.” Fungi Magazine, 2021.
  • Carhart-Harris R, et al. “Psilocybin and neuroplasticity.” New England Journal of Medicine, 2021.
  • Johns Hopkins Psilocybin Research — microdosing studies 2023–2025.
  • Oregon Psilocybin Services — Measure 109 clinical outcomes.

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